New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.

doi:10.1021/jm9800595

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Article

New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.

Journal of medicinal chemistry - 4 Jun 1998

Cushman M, Casimiro-Garcia A, Hejchman E, Ruell J A, Huang M, Schaeffer C A, Williamson K, Rice W G, Buckheit R W

Abstract excerpt

Twenty-two new alkenyldiarylmethanes (ADAMs) were synthesized and evaluated for inhibition of HIV-1 replication. The most potent compound proved to be methyl 3',3"-dichloro-4',4"-dimethoxy-5', 5"-bis(methoxycarbonyl)-6,6-diphenyl-5-hexenoate (ADAM II), which displayed an EC50 of 13 nM for inhibit...

Topics

Alkanes
Animals
Anti-HIV Agents
Binding Sites
Caproates
Cell Line
Cytopathogenic Effect, Viral
Drug Evaluation, Preclinical
Drug Resistance, Microbial
HIV Reverse Transcriptase
HIV-1
Leukocytes, Mononuclear
Macrophages
Mice

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Mutation

Reverse Transcriptase Inhibitors

Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 9622549
DOI: 10.1021/jm9800595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9622549-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.