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Article

Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.

Journal of medicinal chemistry - 4 Oct 2007

Cullen Matthew D, Deng Bo-Liang, Hartman Tracy L, Watson Karen M, Buckheit Robert W, Pannecouque Christophe, Clercq Erik De, Cushman Mark

Abstract excerpt

Non-nucleoside inhibitors of HIV reverse transcriptase (NNRTIs), albeit not the mainstays of HIV/AIDS treatment, have become increasingly important in highly active antiretroviral therapy (HAART) due to their unique mechanism of action. Several years ago our group identified the alkenyldiarylmethanes (ADAMs) as a potent and novel class of NNRTIs; however, the most active compounds were found to be metabolically...

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PMID: 17803290
DOI: 10.1021/jm070382k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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