Article
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
Journal of medicinal chemistry - 23 Apr 1998
Meier C, Lorey M, De Clercq E, Balzarini J
Abstract excerpt
The synthesis, hydrolysis, and antiviral evaluation of novel, lipophilic cycloSal-d4TMP derivatives 3a-h of the anti-HIV dideoxynucleoside 2',3'-dideoxy-2',3'-didehydrothymidine (d4T, 1) are reported. This pro-nucleotide concept has been designed to deliver d4TMP (2) by selective chemical hydroly...
Topics
- Animals
- Anti-HIV Agents
- Buffers
- Cattle
- Chromatography, High Pressure Liquid
- Drug Delivery Systems
- HIV-1
- HIV-2
- Humans
- Hydrogen-Ion Concentration
- Hydrolysis
- Mutation
- Octanols
- Organophosphates
- Prodrugs
- Solubility
- Stavudine
- Stereoisomerism