Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.

Journal of medicinal chemistry - 23 Apr 1998

Meier C, Lorey M, De Clercq E, Balzarini J

Abstract excerpt

The synthesis, hydrolysis, and antiviral evaluation of novel, lipophilic cycloSal-d4TMP derivatives 3a-h of the anti-HIV dideoxynucleoside 2',3'-dideoxy-2',3'-didehydrothymidine (d4T, 1) are reported. This pro-nucleotide concept has been designed to deliver d4TMP (2) by selective chemical hydrolysis. All compounds 3a-h were synthesized using phosphorus(III) chemistry in good yields and in somewhat lower yields...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Cattle
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Hydrolysis

Share to Mutation

Share to Solubility

Source

Identifiers

PMID: 9554875
DOI: 10.1021/jm970664s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.PMID 9554875Read ↗

"Lock-in" modified cyclosal nucleotides--the second generation of cyclosal prodrugs.Semantic proximity Read ↗

Stereoselective synthesis and antiviral activity of methyl-substituted cycloSal-pronucleotides.Semantic proximity Read ↗

A P(V)-Platform for Oligonucleotide SynthesisSemantic proximity Read ↗

Acyclic nucleoside phosphonates: a key class of antiviral drugsSemantic proximity Read ↗

PDE-stable 2′3′-cGAMP analogues, containing 5′-S-phosphorothioester linkage, as STING agonistsSemantic proximity Read ↗

Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.Semantic proximity Read ↗

Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis.Semantic proximity Read ↗

Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.Semantic proximity Read ↗

ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINESSemantic proximity Read ↗

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.Semantic proximity Read ↗

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity.Semantic proximity Read ↗

Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.