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Article

"Lock-in" modified cyclosal nucleotides--the second generation of cyclosal prodrugs.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2005

Vukadinović D, Böge N P H, Balzarini J, Meier C

Abstract excerpt

A new generation of cycloSal-pronucleotides is presented. CycloSal-d4TMPs have been modified by introduction of an esterase-cleavable site in order to trap them inside cells. Hydrolysis studies in different media (PBS, CEM/0- and liver extracts) and anti-HIV evaluation of separated diastereomers revealed unexpected differences between the isomers.

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PMID: 16248067
DOI: 10.1081/ncn-200059298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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