Article
An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms.
The Journal of pathology - 1 Jan 1994
Baas I O, Mulder J W, Offerhaus G J, Vogelstein B, Hamilton S R
Abstract excerpt
Immunohistochemical detection of intranuclear p53 gene product may indicate mutation of the p53 suppressor gene on chromosome 17p. We used six commercially available antibodies for p53 immunohistochemistry on 19 archival colorectal neoplasms and compared the results with the mutation status of the p53 gene and 17p allelic deletion status. By Friedman's ranking analysis, use of mouse monoclonal antibody DO7 with...
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