Article
Potential false-positive results with antigen enhancement for immunohistochemistry of the p53 gene product in colorectal neoplasms.
The Journal of pathology - 1 Mar 1996
Baas I O, van den Berg F M, Mulder J W, Clement M J, Slebos R J, Hamilton S R, Offerhaus G J
Abstract excerpt
Immunohistochemistry (IHC) for intranuclear p53 gene product is a simple, routine alternative to molecular genetic analysis of the p53 gene. Several methods for antigen enhancement are currently in use for IHC. This study evaluates the effect of extreme antigen enhancement for p53, using a monoclonal antibody (DO7) and a polyclonal antibody (CM1). The cases studied were five colorectal carcinomas, two specimens...
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