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Article

Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1994

Weber J S, Berry J, Manser T, Claflin J L

Abstract excerpt

To study the distribution of somatic mutations in the DNA flanking the 5' side of rearranged Ig V genes, the 5' region of 14 to 21 mutant forms of three different V(D)J were sequenced. These were compared with a fourth V(D)J for which the flanking sequences of 10 mutant forms are known. The leader intron of these four V genes varied from 82 to 365 nucleotides in length. Analysis of the data showed that: 1) The...

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PMID: 7930582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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