Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J.

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Article

Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1994

Weber J S, Berry J, Manser T, Claflin J L

Abstract excerpt

To study the distribution of somatic mutations in the DNA flanking the 5' side of rearranged Ig V genes, the 5' region of 14 to 21 mutant forms of three different V(D)J were sequenced. These were compared with a fourth V(D)J for which the flanking sequences of 10 mutant forms are known. The leade...

Topics

Animals
Base Sequence
DNA Primers
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Mice
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 7930582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7930582-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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