Article
Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia.
Leukemia research - 1 Jul 1998
Misawa S, Horiike S, Kaneko H, Sasai Y, Ueda Y, Nakao M, Yokota S, Taniwaki M, Fujii H, Nakagawa H, Tsuda S, Kashima K
Abstract excerpt
We examined chromosomes and mutations of the N-RAS and TP53 genes in 73 patients with acute myeloid leukemia (AML). Twenty-six patients showed a reciprocal chromosomal translocation or an inversion, and 34 patients showed only unbalanced aberrations. Balanced aberrations were predominantly detect...
Topics
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Chromosome Aberrations
- Chromosomes
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 5
- Chromosomes, Human, Pair 7
- Female
- Genes, p53
- Genes, ras
- Humans
- Karyotyping
- Leukemia, Myeloid