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Article

Significance of chromosomal alterations and mutations of the N-RAS and TP53 genes in relation to leukemogenesis of acute myeloid leukemia.

Leukemia research - 1 Jul 1998

Misawa S, Horiike S, Kaneko H, Sasai Y, Ueda Y, Nakao M, Yokota S, Taniwaki M, Fujii H, Nakagawa H, Tsuda S, Kashima K

Abstract excerpt

We examined chromosomes and mutations of the N-RAS and TP53 genes in 73 patients with acute myeloid leukemia (AML). Twenty-six patients showed a reciprocal chromosomal translocation or an inversion, and 34 patients showed only unbalanced aberrations. Balanced aberrations were predominantly detected in the AML patients who did not have myelodysplasia, preceding myelodysplastic syndrome, and a history of...

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PMID: 9680114
DOI: 10.1016/s0145-2126(98)00056-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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