N-ras and p53 gene mutations in Japanese patients with myeloproliferative disorders.

doi:10.1002/ajh.10188

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Article

N-ras and p53 gene mutations in Japanese patients with myeloproliferative disorders.

American journal of hematology - 1 Oct 2002

Tsurumi Shigeharu, Nakamura Yuichi, Maki Kazuhiro, Omine Mitsuhiro, Fujita Kazuhiro, Okamura Takashi, Niho Yoshiyuki, Hashimoto Sachiko, Kanno Keiko, Suzuki Kenshi, Hangaishi Akira, Ogawa Seishi, Hirai Hisamaru, Mitani Kinuko

Abstract excerpt

Alterations of the N-ras oncogene and p53 tumor suppressor gene have been demonstrated to play an important role in pathogenesis of hematological malignancies. We simultaneously investigated genetic lesions of both genes in bone marrow cells from 64 Japanese patients with myeloproliferative disorders (MPD), including polycythemia vera (PV), essential thrombocythemia (ET), and idiopathic myelofibrosis (MF), by...

Topics

Adult
Aged
DNA Mutational Analysis
Female
Genes, ras
Humans
Japan
Male
Middle Aged
Mutation
Myeloproliferative Disorders
Tumor Suppressor Protein p53

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Identifiers

PMID: 12353315
DOI: 10.1002/ajh.10188

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