Article
Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum.
Cancer research - 15 Mar 2001
Spatz A, Giglia-Mari G, Benhamou S, Sarasin A
Abstract excerpt
Xeroderma pigmentosum (XP) is an inheritable disease characterized by sun-sensitivity and a high frequency of skin cancers including melanoma. We have analyzed two different groups of XP: the XP complementation group C (XP-C), deficient in global nucleotide excision repair but proficient in transcription-coupled repair and associated with a very early onset of skin cancers; and the XP variant (XPV), deficient in...
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