Article
Mutation of the tumor suppressor gene TP53 is not detected in psoriatic skin.
The Journal of investigative dermatology - 1 Jul 1993
Molès J P, Theillet C, Basset-Sèguin N, Guilhou J J
Abstract excerpt
We investigated the tumor-suppressor gene, TP53, in psoriatic skin at gene (GP53) and protein (p53) levels. No mutation was detected in the seven exons analyzed using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques. In addition, by immunohistochem...
Topics
- Base Sequence
- DNA, Single-Stranded
- Genes, Tumor Suppressor
- Humans
- Immunohistochemistry
- Molecular Conformation
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Psoriasis
- Skin
- Tumor Suppressor Protein p53