Article
3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts.
The EMBO journal - 3 Jul 1995
Cicchetti P, Ridley A J, Zheng Y, Cerione R A, Baltimore D
Abstract excerpt
The SH3 binding protein, 3BP-1, was originally cloned as a partial cDNA from an expression library using the Abl SH3 domain as a probe. In addition to an SH3 binding domain, 3BP-1 displayed homology to a class of GTPase activating proteins (GAPs) active against Rac and Rho proteins. We report her...
Topics
- 3T3 Cells
- Actins
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- Cell Membrane
- Fibroblasts
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Gene Expression Regulation
- Genes, src
- Growth Substances
- Guanosine Triphosphate
- Lysophospholipids
- Mice
- Molecular Sequence Data
- Mutation