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Article

SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling.

Nature - 18 Apr 2002

Shinohara Masahiro, Terada Yoh, Iwamatsu Akihiro, Shinohara Azusa, Mochizuki Naoki, Higuchi Maiko, Gotoh Yukiko, Ihara Sayoko, Nagata Satoshi, Itoh Hiroshi, Fukui Yasuhisa, Jessberger Rolf

Abstract excerpt

Phosphoinositide-3-OH kinase (PI(3)K), activated through growth factor stimulation, generates a lipid second messenger, phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3). PtdIns(3,4,5)P3 is instrumental in signalling pathways that trigger cell activation, cytoskeletal rearrangement, survival and other reactions. However, some targets of PtdIns(3,4,5)P3 are yet to be discovered. We demonstrate that...

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PMID: 11961559
DOI: 10.1038/416759a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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