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Article

The phosphoinositide (PI) 3-kinase family

26 Jun 2003

Abstract excerpt

Phosphoinositide (PI) 3-kinase was first observed in 1984 as a minor inositol lipid kinase activity associated with immunoprecipitated oncogene products (e.g. Src, Abl and polyoma mT antigen) and present in activated growth factor receptor complexes (e.g. PDGF receptor). In 1988, the enzyme associated with this activity was found to have the novel ability to phosphorylate the 3 position hydroxyl group of the...

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PMID: 12829733
DOI: 10.1242/jcs.00609

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Source receipt: pubmed, retrieved 7 Sept 2026.

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