Article
Genetic Ablation of PDGF-Dependent Signaling Pathways Abolishes Vascular Remodeling and Experimental Pulmonary Hypertension.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2015
Ten Freyhaus Henrik, Berghausen Eva M, Janssen Wiebke, Leuchs Maike, Zierden Mario, Murmann Kirsten, Klinke Anna, Vantler Marius, Caglayan Evren, Kramer Tilmann, Baldus Stephan, Schermuly Ralph T, Tallquist Michelle D, Rosenkranz Stephan
Abstract excerpt
OBJECTIVE: Despite modern therapies, pulmonary arterial hypertension (PAH) harbors a high mortality. Vascular remodeling is a hallmark of the disease. Recent clinical studies revealed that antiremodeling approaches with tyrosine-kinase inhibitors such as imatinib are effective, but its applicability is limited by significant side effects. Although imatinib has multiple targets, expression analyses support a role...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.