Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.

doi:10.1101/gad.9.1.108

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Article

Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.

Genes & development - 1 Jan 1995

Rancourt D E, Tsuzuki T, Capecchi M R

Abstract excerpt

hoxb-5 and hoxb-6 are adjacent genes in the mouse HoxB locus and are members of the homeotic transcription factor complex that governs establishment of the mammalian body plan. To determine the roles of these genes during development, we generated mice with a targeted disruption in each gene. Three phenotypes affecting brachiocervicothoracic structures were found in the mutant mice. First, hoxb-5- homozygotes...

Topics

Alleles
Animals
Bone and Bones
CCAAT-Enhancer-Binding Proteins
Cervical Vertebrae
DNA-Binding Proteins
Forelimb
Genes, Homeobox
Genetic Complementation Test
Homeodomain Proteins
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Ribs

Shoulder

Thoracic Vertebrae

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 7828847
DOI: 10.1101/gad.9.1.108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7828847-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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