Article
Strand specificity and absence of hot spots for p53 mutations in ultraviolet B-induced skin tumors of XPA-deficient mice.
Cancer research - 15 Feb 1998
Takeuchi S, Nakatsu Y, Nakane H, Murai H, Hirota S, Kitamura Y, Okuyama A, Tanaka K
Abstract excerpt
We examined the spectrum of p53 mutations found in 40 UV-induced skin tumors of xeroderma pigmentosum group A gene (XPA)-deficient mice. p53 mutations were detected in 48% of the tumors. Nearly all of the mutations were induced at dipyrimidine sites. Ninety-three % of the mutations were G.C-->A.T...
Topics
- Animals
- Base Sequence
- Genes, p53
- Humans
- Mice
- Mice, Mutant Strains
- Mutation
- Neoplasms, Radiation-Induced
- Skin Neoplasms
- Ultraviolet Rays
- Xeroderma Pigmentosum