A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.

doi:10.1101/gad.7.10.1966

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Article

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.

Genes & development - 1 Oct 1993

Harrison D A, Gdula D A, Coyne R S, Corces V G

Abstract excerpt

The suppressor of Hairy-wing [su(Hw)] protein mediates the mutagenic effect of the gypsy retrotransposon by repressing the function of transcriptional enhancers controlling the expression of the mutant gene. A structural and functional analysis of su(Hw) was carried out to identify domains of the...

Topics

Amino Acid Sequence
Animals
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Chromosome Mapping
Conserved Sequence
DNA Mutational Analysis
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression Regulation

Infertility, Female

Insect Hormones

Insect Proteins

Leucine Zippers

Male

Source

Open in PubMed

Identifiers

PMID: 7916729
DOI: 10.1101/gad.7.10.1966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7916729-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.PMID 7916729Read ↗

The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein.Semantic proximity Read ↗

The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.Semantic proximity Read ↗

The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon.Semantic proximity Read ↗

Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.Semantic proximity Read ↗

The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.Semantic proximity Read ↗

Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.Semantic proximity Read ↗

Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila.Semantic proximity Read ↗

Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary.Semantic proximity Read ↗

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