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Article

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.

Genes & development - 1 Oct 1993

Harrison D A, Gdula D A, Coyne R S, Corces V G

Abstract excerpt

The suppressor of Hairy-wing [su(Hw)] protein mediates the mutagenic effect of the gypsy retrotransposon by repressing the function of transcriptional enhancers controlling the expression of the mutant gene. A structural and functional analysis of su(Hw) was carried out to identify domains of the protein responsible for its negative effect on enhancer action. Sequence comparison among the su(Hw) proteins from...

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Identifiers

PMID: 7916729
DOI: 10.1101/gad.7.10.1966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.PMID 7916729Read ↗

The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein.Semantic proximity Read ↗

The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.Semantic proximity Read ↗

The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon.Semantic proximity Read ↗

Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.Semantic proximity Read ↗

The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.Semantic proximity Read ↗

Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.Semantic proximity Read ↗

Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila.Semantic proximity Read ↗

Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary.Semantic proximity Read ↗

Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster.Semantic proximity Read ↗

Dissecting the mechanisms of suppressor of hairless function.Semantic proximity Read ↗

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