Article
The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.
The EMBO journal - 1 Feb 1993
Roseman R R, Pirrotta V, Geyer P K
Abstract excerpt
Mutations in the suppressor of Hairy-wing [su(Hw)] locus reverse the phenotype of a number of tissue-specific mutations caused by insertion of a gypsy retrotransposon. The su(Hw) gene encodes a zinc finger protein which binds to a 430 bp region of gypsy shown to be both necessary and sufficient for its mutagenic effects. su(Hw) protein causes mutations by inactivation of enhancer elements only when a su(Hw)...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Base Sequence
- Chromosomes
- DNA
- DNA Transposable Elements
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Enhancer Elements, Genetic
- Eye Color
- Eye Proteins
- Gene Expression Regulation
- Genotype