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Article

The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.

Genetics - 1 Oct 1993

Kim J, Shen B, Dorsett D

Abstract excerpt

Many mutations in Drosophila melanogaster are gypsy retrotransposon insertions. Gypsy binds the protein (SUHW) encoded by the suppressor of Hairy-wing [su(Hw)] gene, and SUHW alters expression of surrounding genes. When gypsy is between an enhancer and promoter, SUHW blocks activation of transcription by the enhancer. Additionally, when gypsy is downstream of a promoter in a parallel orientation, SUHW increases...

Topics

Animals
Base Sequence
DNA Transposable Elements
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Fungal Proteins
Gene Expression Regulation, Fungal
Genetic Vectors
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Oligodeoxyribonucleotides

Repressor Proteins

Retroviridae

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 8243999
DOI: 10.1093/genetics/135.2.343
PMCID: PMC1205640

Genes

CYC1
GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8243999-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.PMID 8243999Read ↗

The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein.Semantic proximity Read ↗

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.Semantic proximity Read ↗

The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon.Semantic proximity Read ↗

Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.Semantic proximity Read ↗

An endogenous suppressor of hairy-wing insulator separates regulatory domains in Drosophila.Semantic proximity Read ↗

Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.Semantic proximity Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

Genomic organization of gypsy chromatin insulators in Drosophila melanogaster.Semantic proximity Read ↗

DNA position-specific repression of transcription by a Drosophila zinc finger protein.Semantic proximity Read ↗

Insertions of hybrid P elements in the yellow gene of Drosophila cause a large variety of mutant phenotypes.Semantic proximity Read ↗

Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster.Semantic proximity Read ↗

An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila.Semantic proximity Read ↗

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