Article
Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila.
Genetics - 1 Aug 1993
Dorsett D
Abstract excerpt
When the gypsy retrotransposon of Drosophila inserts between an enhancer and promoter it prevents the enhancer from activating transcription. Enhancers are blocked because the protein (SUHW) encoded by the suppressor of Hairy-wing [su(Hw)] gene binds to gypsy. For example, gypsy insertions in an...
Topics
- Alleles
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Enhancer Elements, Genetic
- Insect Hormones
- Insect Proteins
- Nuclear Proteins
- Phenotype
- Repressor Proteins
- Suppression, Genetic
- Temperature
- Transcription Factors