Article
Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.
Biochemical and biophysical research communications - 15 Sept 1994
Tohda H, Yasui A, Yasumoto T, Nakayasu M, Shima H, Nagao M, Sugimura T
Abstract excerpt
Two Chinese hamster ovary cell clones resistant to okadaic acid (OA) were isolated. The OA-resistance was associated with resistance to colchicine, Vinca alkaloids and inhibitors of DNA topoisomerase (topo) II. Drug accumulation assays showed that the intracellular levels of OA, vinblastine and v...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- CHO Cells
- Carrier Proteins
- Colchicine
- Cricetinae
- DNA Topoisomerases, Type II
- Drug Resistance
- Ethers, Cyclic
- Membrane Glycoproteins
- Okadaic Acid
- Phenotype
- Topoisomerase II Inhibitors
- Vinblastine
- Vinca Alkaloids
- Vincristine