Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.

Biochemical and biophysical research communications - 15 Sept 1994

Tohda H, Yasui A, Yasumoto T, Nakayasu M, Shima H, Nagao M, Sugimura T

Abstract excerpt

Two Chinese hamster ovary cell clones resistant to okadaic acid (OA) were isolated. The OA-resistance was associated with resistance to colchicine, Vinca alkaloids and inhibitors of DNA topoisomerase (topo) II. Drug accumulation assays showed that the intracellular levels of OA, vinblastine and vincristine, but not the topo II inhibitor etoposide, were significantly lowered in the OA-resistant mutants than in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to CHO Cells

Share to Cricetinae

Share to DNA Topoisomerases, Type II

Share to Membrane Glycoproteins

Share to Phenotype

Source

Identifiers

PMID: 7916570
DOI: 10.1006/bbrc.1994.2311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.PMID 7916570Read ↗

Unstable expression of the multi-drug-resistant phenotype in Chinese hamster ovary cells resistant to okadaic acid.Semantic proximity Read ↗

Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells.Semantic proximity Read ↗

Establishment of okadaic acid resistant cell clones using a cDNA expression library.Semantic proximity Read ↗

Human leukemia K562 cell mutant (K562/OA200) selected for resistance to okadaic acid (protein phosphatase inhibitor) lacks protein kinase C-epsilon, exhibits multidrug resistance phenotype, and expresses drug pump P-glycoprotein.Semantic proximity Read ↗

Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines.Semantic proximity Read ↗

Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells.Semantic proximity Read ↗

Characterization of auromomycin-resistant hamster cell mutants that display a multidrug resistance phenotype.Semantic proximity Read ↗

[Incidence of mutation and deletion in topoisomerase II mRNA of etoposide and m-AMSA resistant cell lines].Semantic proximity Read ↗

Nalidixic acid-resistant V79 cells with reduced DNA topoisomerase II activity and amplification prone phenotype.Semantic proximity Read ↗

Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides.Semantic proximity Read ↗

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.Semantic proximity Read ↗

Multidrug resistance in rat colon carcinoma cell lines CC531, CC531mdr+ and CC531rev.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.