Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells.

doi:10.1073/pnas.91.20.9267

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Article

Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 1994

Shima H, Tohda H, Aonuma S, Nakayasu M, DePaoli-Roach A A, Sugimura T, Nagao M

Abstract excerpt

Okadaic acid (OA)-resistant variants of Chinese hamster ovary cells, clones CHO/OAR6-6 and CHO/OAR2-3, were isolated from a CHO-K1 culture. These variant cells were 17- to 26-fold more resistant to OA than the parental cells. The phosphorylase phosphatase activity of the variant cell extracts was...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Amino Acid Sequence
Animals
Base Sequence
CHO Cells
Clone Cells
Cloning, Molecular
Cricetinae
DNA Primers
Drug Resistance
Ethers, Cyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Isoenzymes

Macromolecular Substances

Molecular Sequence Data

Okadaic Acid

Phosphoprotein Phosphatases

Point Mutation

Source

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Identifiers

PMID: 7937753
DOI: 10.1073/pnas.91.20.9267
PMCID: PMC44793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7937753-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells.PMID 7937753Read ↗

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