Article
Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells.
Journal of cancer research and clinical oncology - 1 Jul 2002
Lage Hermann, Dietel Manfred
Abstract excerpt
PURPOSE: Drug-resistant phenotypes of cancer cells may be caused by complex multimodal mechanisms of resistance. In order to gain further insighte into these mechanisms, a P-glycoprotein-mediated multidrug-resistant phenotype induced by daunorubicin-selection and an alternative drug resistance due to treatment with mitoxantrone were investigated in pancreatic carcinoma-derived cells. METHODS: For assessing...
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