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Article

Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines.

Japanese journal of cancer research : Gann - 1 Oct 2001

Matsumoto Y, Takano H, Kunishio K, Nagao S, Fojo T

Abstract excerpt

The efficacy of all chemotherapeutic agents is limited by the occurrence of drug resistance. To further understand resistance to topoisomerase II inhibitors, 50 sublines were isolated as single clones from parental cells by exposure to VP-16 (etoposide) or mAMSA (m-amsacrine). Subsequently, a population of cells from each subline was exposed to three-fold higher drug concentrations allowing 16 stable sublines to...

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Identifiers

PMID: 11676865
DOI: 10.1111/j.1349-7006.2001.tb01069.x
PMCID: PMC5926608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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