Article
Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study.
Lancet (London, England) - 30 Jul 1994
Heym B, Honoré N, Truffot-Pernot C, Banerjee A, Schurra C, Jacobs W R, van Embden J D, Grosset J H, Cole S T
Abstract excerpt
Tuberculosis-control programmes are compromised by the increased frequency of multidrug-resistant strains of Mycobacterium tuberculosis. We used the polymerase chain reaction (PCR) and single-strand conformation polymorphism (SSCP) analysis techniques to establish the molecular basis of resistanc...
Topics
- AIDS-Related Opportunistic Infections
- Antitubercular Agents
- Drug Resistance, Microbial
- Ethionamide
- Female
- Genes, Bacterial
- Humans
- Isoniazid
- Male
- Mutation
- Mycobacterium tuberculosis
- Polymerase Chain Reaction
- Retrospective Studies
- Rifampin
- Streptomycin
- Tuberculosis, Multidrug-Resistant