Article
Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives.
Emerging infectious diseases - 1 Jan 2000
Rattan A, Kalia A, Ahmad N
Abstract excerpt
Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either...
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