Article
Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.
The Journal of infectious diseases - 1 Apr 1995
Morris S, Bai G H, Suffys P, Portillo-Gomez L, Fairchok M, Rouse D
Abstract excerpt
The molecular mechanisms of resistance to streptomycin, rifampin, and isoniazid in 53 Mycobacterium tuberculosis clinical isolates were examined. Twenty-five of 44 streptomycin-resistant strains had mutations in the rpsL gene and 5 of these had rrs gene perturbations. The region of the rpoB gene...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Base Sequence
- DNA Mutational Analysis
- DNA-Directed RNA Polymerases
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Genes, Bacterial
- Genetic Markers
- Humans
- Isoniazid
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis
- Oxidoreductases
- Peroxidases
- Polymorphism, Single-Stranded Conformational
- RNA, Ribosomal, 16S