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Article

Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

Clinical microbiology reviews - 1 Oct 1995

Musser J M

Abstract excerpt

The primary theme emerging from molecular genetic work conducted with Mycobacterium tuberculosis and several other mycobacterial species is that resistance is commonly associated with simple nucleotide alterations in target chromosomal genes rather than with acquisition of new genetic elements encoding antibiotic-altering enzymes. Mutations in an 81-bp region of the gene (rpoB) encoding the beta subunit of RNA...

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Identifiers

PMID: 8665467
DOI: 10.1128/CMR.8.4.496
PMCID: PMC172873

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