Article
[Accumulation of gene alterations and progression of breast cancer].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jun 1994
Tsuda H
Abstract excerpt
A number of gene alterations have been detected in human breast cancer, and their clinicopathological implications have been investigated. Amplification of the c-erb B-2 gene and point mutations of the p53 gene are shown to be associated with biological aggressiveness of cancer cells, whereas los...
Topics
- Breast Neoplasms
- Chromosomes, Human, Pair 16
- ErbB Receptors
- Female
- Gene Amplification
- Gene Deletion
- Genes, p53
- Humans
- Phenotype
- Point Mutation
- Proto-Oncogene Proteins
- Receptor, ErbB-2