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Article

[Diagnosis of HER2 gene amplification in breast carcinoma].

Pathologie-biologie - 1 Sept 2008

Couturier J, Vincent-Salomon A, Mathieu M-C, Valent A, Bernheim A

Abstract excerpt

Amplification of the HER2 gene, mapping to 17q21.1, is present in about 20 % of breast carcinomas. Amplification leads to an overexpression of the protein that made it possible to develop a targeted therapy by the monoclonal antibody trastuzumab (Herceptin). A good response to the treatment requires a stringent assessment of the gene status in tumours; only patients whose tumour shows a high expression of the...

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Share to Aneuploidy
Share to Antibodies, Monoclonal, Humanized
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 17

Share to Gene Amplification

Share to Genes, erbB-2

Share to Trastuzumab

Source

Identifiers

PMID: 18456424
DOI: 10.1016/j.patbio.2008.03.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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