[Clinicopathological implications of gene alterations in breast cancer].

Abstract excerpt

Recently, many alterations in DNA were demonstrated in human breast cancer in vivo, and their clinical and pathological implications were extensively examined. Among these gene alterations, amplification of the c-erbB-2 proto-oncogene and mutation of the p53 tumor-suppressor gene, which occur relatively frequently and are accompanied by alterations in the respective protein levels, demonstrated strong correlation...

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