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Article

Expression of DNA damage response genes indicate progressive breast tumors.

Cancer letters - 18 Jan 2009

Gochhait Sailesh, Dar Surabhi, Pal Ranjana, Gupta Pawan, Bamezai Rameshwar N K

Abstract excerpt

To assess how the abnormal expression of DNA damage response (DDR) genes correlate with oncogenesis, we analyzed mRNA levels of ATM-CHK2-P53 axis in 65 sporadic breast tumors by real-time PCR followed by evaluation of P53 protein and its activation status in representative samples. Univariate analysis showed a significantly higher transcript level for ATM (P=0.002), MDM2 (P=0.015) and p21 (P=0.013) in stage 1...

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Share to Cyclin-Dependent Kinase Inhibitor p21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Identifiers

PMID: 18805634
DOI: 10.1016/j.canlet.2008.08.009

Genes

ATM
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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