Article
Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands.
Developmental biology - 1 Mar 1998
Manley N R, Capecchi M R
Abstract excerpt
The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches. Hoxa3 mutant homozygotes have defects in the development of all three organs. Roles for the Hoxa3 p...
Topics
- Animals
- Animals, Newborn
- Calcitonin
- DNA-Binding Proteins
- Ectoderm
- Gene Dosage
- Genes, Homeobox
- Genotype
- Homeodomain Proteins
- Mice
- Mice, Mutant Strains
- Mutation
- Parathyroid Glands
- Phenotype
- RNA, Messenger
- Thymus Gland
- Thyroglobulin
- Thyroid Gland