Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.

doi:10.1002/(sici)1096-8628(19980707)78:3<271::aid-ajmg13>3.0.co;2-c

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Article

Novel point mutation in exon 10 of the RET proto-oncogene in a family with medullary thyroid carcinoma.

American journal of medical genetics - 7 Jul 1998

Oriola J, Páramo C, Halperin I, García-Mayor R V, Rivera-Fillat F

Abstract excerpt

Medullary thyroid carcinoma (MTC) may occur sporadically or as part of the autosomal dominant multiple endocrine neoplasia type 2 (MEN 2). Three hereditary forms of MEN 2 have been identified: MEN 2A, MEN 2B, and familial MTC (FMTC). Missense germ-line mutations in the RET proto-oncogene have bee...

Topics

Carcinoma, Medullary
Cysteine
DNA Primers
Drosophila Proteins
Exons
Female
Genes, Dominant
Genetic Testing
Genotype
Humans
Male
Multiple Endocrine Neoplasia
Pedigree
Phenotype
Point Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Proto-Oncogene Mas

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Identifiers

PMID: 9677065
DOI: 10.1002/(sici)1096-8628(19980707)78:3<271::aid-ajmg13>3.0.co;2-c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9677065-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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