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Article

Plasmid P1 RepA is homologous to the F plasmid RepE class of initiators.

The Journal of biological chemistry - 13 Feb 2004

Sharma Suveena, Sathyanarayana Bangalore K, Bird Jeremy G, Hoskins Joel R, Lee Byungkook, Wickner Sue

Abstract excerpt

DNA replication of plasmid P1 requires a plasmid-encoded origin DNA-binding protein, RepA. RepA is an inactive dimer and is converted by molecular chaperones into an active monomer that binds RepA binding sites. Although the sequence of RepA is not homologous to that of F plasmid RepE, we found by using fold-recognition programs that RepA shares structural homology with RepE and built a model based on the RepE...

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Identifiers

PMID: 14634015
DOI: 10.1074/jbc.M310917200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Plasmid P1 RepA is homologous to the F plasmid RepE class of initiators.PMID 14634015Read ↗

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New pSC101-derivative cloning vectors with elevated copy numbers.Semantic proximity Read ↗

DNA-binding domain of the RepE initiator protein of mini-F plasmid: involvement of the carboxyl-terminal region.Semantic proximity Read ↗

Location of a P1 plasmid replication inhibitor determinant within the initiator gene.Semantic proximity Read ↗

Site-directed mutations in the repA C-terminal region of plasmid Rts1: pleiotropic effects on the replication and autorepressor functions.Semantic proximity Read ↗

Hexameric RSF1010 helicase RepA: the structural and functional importance of single amino acid residues.Semantic proximity Read ↗

Binding of RepE initiator protein to mini-F DNA origin (ori2). Enhancing effects of repE mutations and DnaJ heat shock protein.Semantic proximity Read ↗

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Replication origin mutations affecting binding of pSC101 plasmid-encoded Rep initiator protein.Semantic proximity Read ↗

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