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Article

Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.

Cell - 20 Apr 1990

Kessel M, Balling R, Gruss P

Abstract excerpt

To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely...

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Identifiers

PMID: 1970515
DOI: 10.1016/0092-8674(90)90810-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.PMID 1970515Read ↗

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Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.Semantic proximity Read ↗

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