Article
Novel pattern of p53 gene mutations in an American black cohort with high mortality from breast cancer.
Lancet (London, England) - 14 May 1994
Blaszyk H, Vaughn C B, Hartmann A, McGovern R M, Schroeder J J, Cunningham J, Schaid D, Sommer S S, Kovach J S
Abstract excerpt
The pattern of acquired mutations in the p53 gene can be used to study differences in factors contributing to carcinogenesis. We investigated mutations in exons 5-9 and adjacent intronic regions in 47 breast cancers of black women from Michigan, a population with the highest breast-cancer mortality in the US. The 16 mutations detected differed from those of other populations. In particular, the black women had an...
Topics
- Base Sequence
- Black People
- Breast Neoplasms
- Cohort Studies
- Female
- Genes, p53
- Humans
- Michigan
- Molecular Sequence Data
- Mutation
- Point Mutation