Article
Identification of polymorphisms in the p53 gene by denaturing gradient gel blots.
Human heredity - 1 Jan 2000
Nogueira C P
Abstract excerpt
Polymorphisms in the tumor suppressor gene p53 were identified by Southern blots of denaturing gradient gels (melting polymorphisms). Five polymorphisms were identified in white blood cell DNA, with the frequency of heterozygotes varying from 4 to 27%. The strategy of hybridizing the same blots w...
Topics
- Breast Neoplasms
- DNA Probes
- DNA, Neoplasm
- Electrophoresis, Polyacrylamide Gel
- Female
- Genes, p53
- Humans
- Lymphocytes
- Mutation
- Polymorphism, Genetic