Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma

11 Feb 2013

Abstract excerpt

PURPOSE: Glioblastoma (GBM) shows downregulated expression of human leukocyte antigen (HLA) class I, thereby escaping from cytotoxic T cells and limiting the efficacy of immunotherapy. Loss of heterozygosity (LOH) of HLA class I (6p21) and/or β-2 microglobulin (B2m) (15q21) regions represents irreversible downregulation. In this study, we examined the prevalence of these LOH events and their relations with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Immunotherapy and Immune Responses
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23401227
DOI: 10.1158/1078-0432.ccr-12-2861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult GlioblastomaPMID 23401227Read ↗

Copy Neutral LOH Affecting the Entire Chromosome 6 Is a Frequent Mechanism of HLA Class I Alterations in CancerSemantic proximity Read ↗

Hemizygous deletions in the HLA region account for loss of heterozygosity in the majority of diffuse large B-cell lymphomas of the testis and the central nervous system.Semantic proximity Read ↗

Distribution of HLA class I altered phenotypes in colorectal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21.Semantic proximity Read ↗

Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs.Semantic proximity Read ↗

HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomasSemantic proximity Read ↗

LOH at 6p21.3 region and HLA class I altered phenotypes in bladder carcinomas.Semantic proximity Read ↗

HLA-G 14 bp In/Del and +3142 C/G genotypes are differentially expressed between patients with grade IV gliomas and controls.Semantic proximity Read ↗

Loss of NOTCH2 Positively Predicts Survival in Subgroups of Human Glial Brain TumorsSemantic proximity Read ↗

Beta2-microglobulin aberrations in diffuse large B-cell lymphoma of the testis and the central nervous system.Semantic proximity Read ↗

HLA polymorphisms and risk of glioblastoma in Koreans.Semantic proximity Read ↗

HLA Polymorphisms and Risk of Glioblastoma in KoreansSemantic proximity Read ↗

Loss of heterozygosity at 6p21 and HLA class I expression in esophageal squamous cell carcinomas in China.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.