Article
Analysis of somatic cell mutations at the glycophorin A locus in atomic bomb survivors: a comparative study of assay methods.
Radiation research - 1 Oct 1993
Langlois R G, Akiyama M, Kusunoki Y, DuPont B R, Moore D H, Bigbee W L, Grant S G, Jensen R H
Abstract excerpt
The glycophorin A (GPA) assay for in vivo somatic cell mutations was performed on blood samples from 39 survivors of the atomic bomb at Hiroshima. Parallel analyses were performed at two laboratories using three different GPA assay methods to enumerate cells lacking expression of either the M- or N-allele of GPA. All assay methods yielded significant dose-dependent increases in hemizygous GPA variant cell...
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