Article
Somatic cell mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors: implications for radiation carcinogenesis.
Radiation research - 1 Jul 1996
Kyoizumi S, Akiyama M, Cologne J B, Tanabe K, Nakamura N, Awa A A, Hirai Y, Kusunoki Y, Umeki S
Abstract excerpt
To clarify the relationship between somatic cell mutations and radiation exposure, the frequency of hemizygous mutant erythrocytes at the glycophorin A (GPA) locus was measured by flow cytometry for 1,226 heterozygous atomic bomb (A-bomb) survivors in Hiroshima and Nagasaki. For statistical analysis, both GPA mutant frequency and radiation dose were log-transformed to normalize skewed distributions of these...
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