Article
T cell influence on superantigen-induced arthritis in MRL-lpr/lpr mice.
Arthritis and rheumatism - 1 Jan 1994
Mountz J D, Zhou T, Long R E, Bluethmann H, Koopman W J, Edwards C K
Abstract excerpt
OBJECTIVE: To define the influence of the T cell receptor (TCR) and the lpr autoimmune gene on the induction and progression of superantigen-induced arthritis in V beta 8 transgenic MRL-lpr/lpr mice. METHODS: The time to onset and the extent of synovial hyperplasia after the induction of arthritis by intraarticular injection of staphylococcal enterotoxin B (SEB) were compared in mice having T cells that bear the...
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