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Article

Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice.

Arthritis and rheumatism - 1 Aug 2006

Berlo Suzanne E, Guichelaar Teun, Ten Brink Corlinda B, van Kooten Peter J, Hauet-Broeren Femke, Ludanyi Katalin, van Eden Willem, Broeren Chris P, Glant Tibor T

Abstract excerpt

OBJECTIVE: To better understand the role of antigen (arthritogenic epitope)-specific T cells in the development of autoimmune arthritis. METHODS: A transgenic (Tg) mouse expressing the T cell receptor (TCR) Valpha1.1 and V(beta)4 chains specific for a dominant arthritogenic epitope (designated 5/4E8) of human cartilage proteoglycan (HuPG) aggrecan was generated. This TCR-Tg mouse strain was backcrossed into the...

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PMID: 16869010
DOI: 10.1002/art.22013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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