Article
Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie.
The Journal of general virology - 1 Dec 2000
Andréoletti Olivier, Berthon Patricia, Marc Daniel, Sarradin Pierre, Grosclaude Jeanne, van Keulen Lucien, Schelcher François, Elsen Jean-Michel, Lantier Frédéric
Abstract excerpt
The immune system is known to be involved in the early phase of scrapie pathogenesis. However, the infection route of naturally occurring scrapie and its spread within the host are not entirely known. In this study, the pathogenesis of scrapie was investigated in sheep of three PrP genotypes, from 2 to 9 months of age, which were born and raised together in a naturally scrapie-affected Romanov flock. The kinetics...
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