Article
PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration - 1 Dec 1994
Manson J C, Clarke A R, McBride P A, McConnell I, Hope J
Abstract excerpt
We have produced by gene targeting a mouse line with an inactive PrP gene. In animals heterozygous for this mutation, PrP mRNA is reduced by approximately 50% throughout the brain compared with wild type mice. The steady-state level of PrPc is also significantly reduced in heterozygotes compared to wild type mice. PrP mRNA and protein are not detected in brains of mice homozygous for the mutation. We have...
Topics
- Alleles
- Animals
- Gene Dosage
- Heterozygote
- Mice
- Mice, Neurologic Mutants
- Phenotype
- PrPSc Proteins
- RNA, Messenger
- Scrapie
- Time Factors