Article

Host prion protein expression levels impact prion tropism for the spleen

2019-12-17

Abstract excerpt

Prions are pathogens formed from abnormal conformers (PrP Sc ) of the host-encoded cellular prion protein (PrP C ). PrP Sc conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-specific tropism for lymphoid tissues. Prions can be composed of several substrain components. There is evidence that these substrains can propagate in distinct tissu...

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Literature Corpus work: 7e5211c9-669a-5d1a-8e26-6262cd76f44f
DOI: 10.1101/2019.12.17.879676

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