Article
A new high frequency polymorphism in the HER-2/neu oncogene in normal tissue and breast tumors.
Breast cancer research and treatment - 1 Oct 1993
Briscoe W T, Ray D B, Airhart J L, Ratliff A L, Shockley E A, Whetsell L, Schaefer F V, Williams R M
Abstract excerpt
The HER-2/neu (erbB-2) oncogene, if amplified and/or overexpressed in breast and ovarian cancers, is associated with a poor prognosis. Employing direct DNA sequencing, we have discovered and sequenced an 80 base pair intron from human placenta which contains an A to G polymorphism. This polymorph...
Topics
- Base Sequence
- Breast
- Breast Neoplasms
- DNA, Neoplasm
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genetic Variation
- Genotype
- Humans
- Introns
- Lymphocytes
- Molecular Sequence Data
- Oncogene Proteins, Viral
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptor, ErbB-2