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Article

Genetic variants in the HER2 gene: Influence on HER2 overexpression and loss of heterozygosity in breast cancer.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2016

Cresti Nicola, Lee Joanne, Rourke Emma, Televantou Despina, Jamieson David, Verrill Mark, Boddy Alan V

Abstract excerpt

Human epidermal growth factor receptor 2 (HER2) overexpression in breast cancer is an indicator of poor prognosis and is the pre-requisite for treatment with the agents targeting this member of the epidermal growth factor receptor family. In order to determine the influence of these common single-nucleotide polymorphisms (SNPs) in the HER2 gene, genomic DNA was obtained from 361 patients with breast cancer, aged...

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Share to Gene Expression Regulation, Enzymologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26773371
DOI: 10.1016/j.ejca.2015.10.066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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