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Article

Ethnic variation in the HER-2 codon 655 genetic polymorphism previously associated with breast cancer.

Journal of human genetics - 1 Jan 2002

Ameyaw Margaret-Mary, Tayeb Mohammed, Thornton Nadia, Folayan Gbolshan, Tariq Mohammed, Mobarek Abeer, Evans David A, Ofori-Adjei David, McLead Howard L

Abstract excerpt

HER-2, a protooncogene located on chromosome 17q21, encodes a transmembrane glycoprotein (p185) with tyrosine kinase activity. Alterations of the HER-2 gene have been implicated in the carcinogenesis and prognosis of breast cancer and other solid tumors. It is also a cancer-therapeutic target for antibody-based therapy against the HER-2 protein. A single-nucleotide polymorphism (SNP) at codon 655, resulting in a...

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Identifiers

PMID: 12166652
DOI: 10.1007/s100380200019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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